Change of the human microbe line has stayed a far off yet important target for most researchers since the rise of hereditary qualities (and even previously). In order to investigate the project's historical transformations, I have chosen three periods-the 1930s, when eugenics was at its height, 1974, when molecular biology took over, and the present-and adopted three criteria to estimate the project's viability: the state of scientific knowledge, the availability of appropriate tools, and the demands of society. Although the long-awaited methods for altering the germ line are now available, I will demonstrate that the majority of the project's expectations have vanished or are thought to be reachable with very different approaches.