There is no argument that caloric manipulation holds an indisputable importance in weight loss management programs. The scientific community, however, would agree that mounting evidence on other non-calorie related weight lowering potentials of foods have not been used as much as they merit in current obesity clinical trials. For example, intestinal microbiota balance manipulation has been proposed as an auxiliary method to weight loss diets in addition to calorie restriction or manipulation. In planning a diet, imagine that we just focus on calorie content of, let us say an apple and forget about its high satiety index or its high polyphenol content that might help weight loss irrespective of caloric considerations.