Magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) were combined to create drug-carrying magnetic nanocomposite spheres for magnetic targeted drug delivery. Through the chemical coprecipitation of ferric and ferrous chloride salts in the presence of a potent basic solution, magnetic nanoparticles of magnetite (average size: 13 nm) were created (ammonium hydroxide). For the synthesis of nanocomposite spheres, an oil-in-oil emulsion/solvent evaporation process was used, with agitation lasting 1.5 to 2 hours at 7000 rpm. Specifically, acetonitrile (oily phase I) was used to dissolve the PLGA and drug, which was subsequently mixed with magnetic nanoparticles. Next, Span 80- and viscous paraffin oil-containing droplets were added in a dropwise fashion (oily phase II). Using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and a superconducting quantum interference device, the nanocomposite spheres with various amounts (0%, 10%, 20%, and 25%) of magnetite were assessed in terms of particle size, morphology, and magnetic properties (SQUID). According to the findings, nanocomposite spheres with diameters ranging from 200 nm to 1.1 m are superparamagnetic over blocking temperatures close to 40 K and reach magnetization saturation beyond 5,000 Oe at ambient temperature.