COVID-19 pandemic, induces a viral protein called open reading frame 3b(ORF3b) actively blocks the induction of type I interferon which are polypeptides that are secreted by infected cells antiviral defense called interferon, that produced by sick cells originally from ribosomal functions, which plays a really important role in slowing virus infection . Interferon is considered to be the initiative primary messages started from ribosome in the infected cells to follow the right original biological pathways to reach brain for asking for protection, recoveries and facing the viral infection. When Corona virus Started to infect human body started by respiratory system, that to minimize the intake oxygen to infected body , that when viral effects reach the blood stream in arteries & in capillaries wil affects on red blood cells to lysis & break their main - ve linkages which original presence in ATP molecules to restore their O2, phosphate gps, & their attached biological peptides that will bind & connected to viral protein to follow viral metabolism and viral toxic productions. Then the result will be reduction in gas exchanges in lungs that the intake oxygen will be minimized, and the restored CO2 in tissues & capillaries will be increased, that will leads to increase toxicities in capillaries then in arteries. When virus start to infect respiratory cells, first will lysis and destroy actin filaments and their isoform including their ATPase which considered to be a part of G-actin filaments