Effect of Levothyroxine Replacement on Testosterone, Lh, Fsh Levels in Men with Over Hypothyroidism

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Aim- to study the effect of hypothyroidism on testicular function, and the effect of post levothyroxine replacement on testicular function. Methods and materials- this study was done in r&r hormone clinic in central part of india, the study was interventional. 21 naïve overtly hypothyroid male patient were taken in this study. The hormones essayed were free testosterone, lh, fsh, t3, t4, tsh before and after 4 months of levothyroxine replacement therapy. Additional adams questionnaire was included in this study to evaluate the prevalance of sexual disturbance in these patients. Proper consent was taken from the patients. Inclusion criteria- newly diagnosed hypothyroid male 20—50 years Exclusion criteria- History of diabetes mellitus; History of hypertension; History of testicular trauma; History of hormonal replacement therapy; History of smoking, chronic alcoholism Result- 50% of patients (10/21) at baseline had low free testosterone level value, mean value of 10-12% had low lh level value(3/21 patients), 88-90% has normal lh value(18/21 patients), fsh values of all the patients was normal, 60 % of patients has low adams score(12/21 patients). After 4 months of therapy on restoration of euthyroidism 8 out of 10 (90%) hypogonadotropic patients the free testosterone level came normal (>300mg/dl), lh value of all the patients restored to normal values, 80% of the patients with low adams score showed improvement in their parameters. Conclusion- there is a high prevalance of hypogonadism in hypothyroid male patients which seemed to be improved significantly after levothyroxine therapy.