The prevalence of type 2 diabetes mellitus (DM) and obesity is actually mountingspeedily in Westernized and developing countries. Type 2 diabetes (T2D) is a complex pathology with several risk factors.It is recently known through several studies that postprandial hyperlipemia is a significant and independent risk factor for cardiovascular disease. In fact, numerous alterations in plasma lipid and lipoprotein concentrations are found in obese patients. The study, which concerned 51 patients with type 2 diabetes, took place in Diabetic Center (Ex. Gambetta) and in the division of Diabetes and Endocrinology at University Hospital (Hassani Abdelkader, Sidi-Bel-Abbès). The aim was to evaluate the relationship between the postprandial lipemia response and overweight and obesity in the type 2 diabetes. The weight, height, waist and hip circumferences, Body Mass Index (BMI) and Waist to Hip Ratio (WHR) were measured. Blood samples were analyzed for total cholesterol, glucose, triglycerides, HDL-cholesterol and LDL-c 2h after meal, fasting glucose. The obtained result determined a correlation between postprandial triglycerides concentration and the BMI especially in overweight and obese women with r 2 = 0.09 and correlation r 2 = 0.01 for men. PPHDL-c was highly elevated among women than men with a significant differences (60.44± 24.17 mg/dL vs. 43.30±18.27 mg/dL; p = 0.016).PPTG among women than men with significant differences (168.33±71.37 mg/ dL vs.121.87±60.84 mg/dL; p=003).It has been noticed that the PPHDL-c was inversely linked to fasting glucose levels (r 2 =0.07) and to the BMI values (r=0.12; p=0.34) among women. The management and loss of weight still indispensible for type 2 diabetic subjects especially overweight and obese women one to avoid postprandial hypertriglyceridemia and its complications mainly coronary heart disease.