Plant diseases, caused by pathogens, significantly reduce food production particularly in the developing world where farmers have little knowledge of these pests. In sericulture, mulberry is an economical plant because silk production depends on the nutritive quality of the leaves which is hampered by various pathogen attacks like nematodes, fungus, virus, bacteria and insects etc. Recently, synthetic- and chemical- pesticides are the most effective means of control, but they are both expensive and environmentally unfriendly. The “evils” of synthetic- and chemical- pesticides has been a major concern to environmentalists. The use of chemical pesticides may achieve a measure of control of those mulberry diseases but there remains the problem of residual toxicity in the treated plants and this toxicity results in reduced palatability of the leaves to the feeding silkworm larvae, reduction in growth of the larvae and also in silk production. These are serious issues which directly cause crises of financial losses, food productions, and climatic changes, but in combination, their impact could be catastrophic for the global economy. To move forward will require new and more efficient solutions, technologies and products. Climate change and resource productive economies are now universally recognized as a significant global environmental challenge. To meet the challenge of the problems, a number of plant bio-nematicides though effective and easily biodegradable are not easily available in large quantities from natural sources and isolation of only a small quantity of an effective metabolites requires huge quantities of plant materials. This would result in rapid depletion of natural resources, particularly in tropical regions. Indiscriminate use of plant resources have already created problem of biodiversity conservation in the world. Bio-nematicides from animal origin (like nematode extract) reduce nematodes infestation in different plants and root callous by using their defense- response against nematode infection. But it remains as a problem.