Several organic compounds showing anti-malarial activities such as aminoquinolines , 3,4,5-hydroxybenzoic acid, 2-hydroxybenzoic acid derivatives  and hydroxynaphthoic acid  have clear and distinct acid base properties as well as hydrogen bond abilities. Due to acid-base properties associated with quinolines and carboxylic acids, they are suitable to form salts and co-crystals. Formation of a salt between two active pharmaceutical ingredients leaves scope to bring together two potent molecules easily to make a stable formulation which may act altogether in different manners. Recently activity of several antimalarial drug molecules have been reviewed and showed how such combinations in the form of co-crystal formed through weak interactions can alter antimalarial drug activities. On other hand protein–myosin a complex has important role in regulating depletion of red blood cells caused by the Plasmodium during malaria.