/ŶƚƌŽĚƵĐƟŽŶ͗ Arterio Venous Fistulas (AVFs) may be radiocephalic, brachiocephalic or brachiobasilic, however a radio-cephalic access is preferred for ƉĂtiÄžnƚƐ with end stage renal disease requiring haemodialysis. ŌĞƌ their cƌĞĂtiŽnÍ• the minimum timÄž for AVF mĂƚƵƌĂtiŽn is around two months. Primary AVF failure is ĚĞĮnĞĚ as an AV ĮƐƚƵůĂ that is never usable or fails within the ĮƌƐƚ three months of its use. There are several ŽbƐĞƌvÄ‚tiŽnƐ that indicate the role of ŝnŇĂmmÄ‚tiŽn in failure of AVF. Elevated CRP has been observed to be associated with early ĮƐƚƵůĂ failure and our study purported to correlate the same. Methodology: In this pilot study, 50 ƉĂtiÄžnƚƐ of end stage renal disease (ESRD) over 18 years of age, ĂŌĞƌ ĨƵůĮůůŝnŐ inclusion and exclusion criteria, underwent the cƌĞĂtiŽn of a radio-cephalic AVF. All ƉĂtiÄžnƚƐ had ƉƌĞͲŽƉĞƌĂtivÄž values of CRP, haemoglobin and albumin ĞƐtimĂƚĞĚ͕ which were repeated again on ƉŽƐƚͲŽƉĞƌĂtivÄž day 2. All ƉĂtiÄžnƚƐ were followed for three months to assess for primary failure of ĮƐƚƵůĂ͘ Results: Out of the 50 ƉĂtiÄžnƚƐ included in the study, six ƉĂtiÄžnƚƐ were lost to follow up. The mean age of the ƉĂtiÄžnƚƐ was 41.48 ±13.46 years. 31.8% (14 ƉĂtiÄžnƚƐͿ developed primary failure of the AVF. No ƐŝŐnŝĮcÄ‚nÆš cŽƌƌĞůĂtiŽn was ŝĚĞntiĮĞĚ between primary failure of AVF and the ƉƌĞͲŽƉĞƌĂtivÄž hemoglobin and albumin levels. While a ƉƌĞͲŽƉĞƌĂtivÄž CRP level<1 mg/dl did not show a ƐŝŐnŝĮcÄ‚nÆš cŽƌƌĞůĂtiŽn with failure of AVF, 71.4% of failed ĮƐƚƵůĂƐ showed CRP levels> 5.4 mg/dl (p=0.025, Sn: 71.43%, Sp: 66.7%). Number of dialysis per week through other sites, and cŽmŽƌbŝĚŝtiĞƐ like hypertension and diabetes mellitus did not show any ƐŝŐnŝĮcÄ‚nÆš ĂƐƐŽcŝĂtiŽn with primary failure of AVF.