Recent advances in orthopedic implants have led to more surgical options and better patient outcomes. The demand for joint replacement surgery is increasing in geriatric patients, with a decline in the average age of patients. Moreover, the number of patients who undergo multiple joint replacement surgeries is increasing. With increasing numbers of orthopedic surgeries, complications following arthroplasty have gained attention. The major perioperative complication is Periprosthetic Joint Infection (PJI, which may burden medical resources and is associated with significant medical expenses and poor clinical outcomes. Patients with PJI often suffer from complications during treatment.