The current study was performed to assess the serological aspects of dengue infected ƉĂƟĞnƚƐ during 2018 at District Shangla, Khyber Pakhtunkhwa, Pakistan. During 2018, a total of 1447 visited these hospitals. Blood samples from the ƉĂƟĞnƚƐ at pathology laboratory. The data was taken from hospitals for the span of 5 months (August to December). A separate form was used to nŽƟcĞ the gender and history of the individuals. The blood samples collected were screened for Dengue ŝnĨĞcƟŽn with the help of BIOLINE Dengue NS 1 Ag+Ab Combo Test. A total of 1447 blood samples were screened. Among them 554 were found ƉŽƐŝƟvĞ for dengue fever whose acquired percentage was (38.28%), while 893 (61.71%) samples were determined with the nĞŐĂƟvĞ outcome. With respects to ƉĂƟĞnƚƐ age groups, there were 271 ƉĂƟĞnƚƐ found ƉŽƐŝƟvĞ with Dengue ŝnĨĞcƟŽn ages of 15 to 35 years with a percentage of (48.91%) which cŽnƐƟƚƵƚĞƐ the majority of majority dengue infected ƉĂƟĞnƚƐ͘ In the month wise ĞƐƟmĂƟŽn of the Dengue severity in the ƉĂƟĞnƚƐ͕ a major outbreak was ŝĚĞnƟĮĞĚ in September and October because of the rainy and post rainy season. It is concluded that approaches including biological, environmental, medicinal, as well as the ĞĚƵcĂƟŽnĂů awareness should be taken to overcome the ŝnĨĞcƟŽn͘ There is also a need of making teams for ŝnvĞƐƟŐĂƟnŐ the real cause and impacts of the dengue fever on the people of the district.