Thiadiazoles compound are the heterocyclic in structure comprising of five-membered nitrogen–sulfur ring system with two nitrogen and one sulfur atom and are broadly present as an important structure in various important active molecules which have medicinal properties. The thiadiazols van also becomes an intermediate in the synthesis of number of other significant medicinal compounds. The different isomeric forms of the thiadiazole such as 1, 2, 3-thiadiazole; 1, 2, 5-thiadiazole; 1, 2, 4-thiadiazole and 1, 3, 4-thiadiazole are found to exist with number of potent activities. The ring contains sulfide linkage, which gives increase activity of thiadiazole; and the physical and chemical properties of thiadiazole can be affected by many other atoms present in the structure such as nitrogen, oxygen and sulfur atoms. Many important medicinal agents such as anti-inflammatory, antimicrobial, antiviral, antiepileptic, antitubercular possess thiadiazol nucleus as a core structure in it. Therefore, thiadiazole is considered to be important scaffold which consists of potent activities.

In the present work described here, we carried out the synthesis of new thiadiazole derivatives from thiosemicarbazide using and the structures of the derivatives were confirmed based on spectral data. Additionally, the derivatives were tested for their anticonvulsant activity and various other important parameters too.