A group of proteins together known as “Interferon” play crucial role in defence mechanism of mammals. Three major group of interferons(INF) include INF-a, INF-b, INF-w etc. These include majority of proteins like INF-a consist of 13 proteins while INF-b has two. The immune cells are the source for their production like macrophages , lymphocytes etc. Also non- immune cells can act so like the fibroblasts , osteoblasts and so on.