The purpose of this brief editorial comment is to highlight the effects of weight loss on health outcome, especially focused on bariatric surgery. Altered life-style and food habits are the commonest forms of the unhealthy gateway, which allows the induction of various deathly disease pathologies in the human body. Obesity is associated with such complications, where excessive intake of fatty foodstuff brings several secondary disease pathologies. The realization from the evil effects of obesity, the awareness of weight loss has come into the act as a therapeutic intervention. The obesity and weight loss therapy deal with the biomedical research of obesity and metabolic disorder. Obesity and metabolic disorder are well-known risk factors for many medical conditions. Therapeutic weight loss including bariatric surgery in overweight or obese individuals can decrease the chance of developing obesity-associated diseases.