Dental and Skeletal Fluorosis are known to occur since many decades in India and other nations. The two disorders are described in detail in publications since early 1930s. But the reasons for the tooth and bone to be attracted by Fluoride are not dealt with. The immediate response is that both tissues are rich in positively charged cations. It may be due to the anion-cation reaction. However, there are other cation rich tissues in the body, which does not get afflicted with Fluoride toxicity along with tooth and bone. Therefore that possibility is ruled out. What could be the other reason(s)? In an adult human body, there are 32 teeth in the oral cavity and 200 bones irrespective of the gender. The disease nomenclature denotes F¯ preferentially afflicted tooth and bone. Those who address the disease(s) should have clarity of thought and reason(s) for the affliction.